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Armistice Capital, LLC
Ghost Tree Capital, LLC
Sphera Funds Management Ltd.
Sabby Management, LLC
Pura Vida Investments, LLC
First Light Asset Management, LLC
Foresite Capital Management Ii, LLC
Casdin Capital, LLC
Opaleye Management Inc.
Boxer Capital, LLC
Versant Venture Management, LLC
Avoro Capital Advisors LLC
Dafna Capital Management LLC
Bvf Inc/il
Rtw Investments, Lp
Perceptive Advisors LLC
Redmile Group, LLC
Vivo Capital, LLC
New Leaf Venture Partners, l.l.c.
Lilly Endowment Inc
Acuta Capital Partners, LLC
Ecor1 Capital, LLC
Aviva Holdings Ltd.
Polaris Venture Management Co. v, l.l.c.
Pfm Health Sciences, Lp
Palo Alto Investors Lp
Great Point Partners LLC
Asymmetry Capital Management, l.p.
Deerfield Management Company, l.p. (Series C)
Foresite Capital Management Iii, LLC
Tamarack Advisers, Lp
Orbimed Advisors LLC
Consonance Capital Management Lp
Sivik Global Healthcare LLC
Lumina Fund Management LLC
New Mountain Vantage Advisers, l.l.c.
Rhenman & Partners Asset Management Ab
Sarissa Capital Management Lp
Baker Bros. Advisors Lp
Greenleaf Trust
Bellevue Group Ag
Cormorant Asset Management, Lp
Sector Gamma As
Rock Springs Capital Management Lp
General Atlantic, l.p.
Omega Fund Management, LLC
Alethea Capital Management, LLC
Healthcor Management, l.p.
Leith Wheeler Investment Counsel Ltd.
Farallon Capital Management LLC