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Armistice Capital, LLC
Ghost Tree Capital, LLC
Sphera Funds Management Ltd.
Sivik Global Healthcare LLC
Sabby Management, LLC
Flagship Pioneering Inc.
Pura Vida Investments, LLC
First Light Asset Management, LLC
Boxer Capital, LLC
Foresite Capital Management Ii, LLC
Casdin Capital, LLC
Opaleye Management Inc.
Avoro Capital Advisors LLC
Lilly Endowment Inc
Acuta Capital Partners, LLC
Vivo Capital, LLC
Bvf Inc/il
Polaris Venture Management Co. v, l.l.c.
Dafna Capital Management LLC
Rtw Investments, Lp
Ecor1 Capital, LLC
Aviva Holdings Ltd.
Pfm Health Sciences, Lp
Versant Venture Management, LLC
Tamarack Advisers, Lp
New Leaf Venture Partners, l.l.c.
Viking Global Investors Lp
Asymmetry Capital Management, l.p.
Lumina Fund Management LLC
Redmile Group, LLC
Greenleaf Trust
Suvretta Capital Management, LLC
Great Point Partners LLC
Orbimed Advisors LLC
Bellevue Group Ag
Rhenman & Partners Asset Management Ab
Krensavage Asset Management, LLC
Biondo Investment Advisors, LLC
Palo Alto Investors Lp
Sector Gamma As
Consonance Capital Management Lp
Omega Fund Management, LLC
Perceptive Advisors LLC
Baker Bros. Advisors Lp
Foresite Capital Management Iii, LLC
Endurant Capital Management Lp
Healthcor Management, l.p.
Highvista Strategies LLC
Rock Springs Capital Management Lp
Bruce & Co., Inc.