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Armistice Capital, LLC
Ghost Tree Capital, LLC
Sivik Global Healthcare LLC
Sabby Management, LLC
Vivo Capital, LLC
Pura Vida Investments, LLC
First Light Asset Management, LLC
Lilly Endowment Inc
Avoro Capital Advisors LLC
Flagship Pioneering Inc.
Regents of the University of California
Pfm Health Sciences, Lp
Tamarack Advisers, Lp
Dafna Capital Management LLC
Lumina Fund Management LLC
Great Point Partners LLC
Acuta Capital Partners, LLC
Rtw Investments, Lp
Greenleaf Trust
Krensavage Asset Management, LLC
Opaleye Management Inc.
Sector Gamma As
Suvretta Capital Management, LLC
Rhenman & Partners Asset Management Ab
Bvf Inc/il
Aviva Holdings Ltd.
Boxer Capital, LLC
Bruce & Co., Inc.
Bellevue Group Ag
Strategic Point Investment Advisors, LLC
Orbimed Advisors LLC
Healthcor Management, l.p.
Berkshire Money Management, Inc.
Kingdon Capital Management, l.l.c.
Ecor1 Capital, LLC
Sio Capital Management, LLC
Casdin Capital, LLC
Consonance Capital Management Lp
Sarissa Capital Management Lp
New Leaf Venture Partners, l.l.c.
New Mountain Vantage Advisers, l.l.c.
Palo Alto Investors Lp
Robert Wood Johnson Foundation
Alethea Capital Management, LLC
Tekla Capital Management LLC
Northwestern University
Endurant Capital Management Lp
Sphera Funds Management Ltd.
Sv Health Investors, LLC
Rock Springs Capital Management Lp