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Armistice Capital, LLC
Lion Point Capital, Lp
Ghost Tree Capital, LLC
Sphera Funds Management Ltd.
Sabby Management, LLC
Pura Vida Investments, LLC
First Light Asset Management, LLC
Caxton Corp
Versant Venture Management, LLC
Aviva Holdings Ltd.
Opaleye Management Inc.
Avoro Capital Advisors LLC
Casdin Capital, LLC
Boxer Capital, LLC
Perceptive Advisors LLC
New Leaf Venture Partners, l.l.c.
Dafna Capital Management LLC
Redmile Group, LLC
Bvf Inc/il
Ra Capital Management, l.p.
Foresite Capital Management Ii, LLC
Acuta Capital Partners, LLC
Crestline Management, Lp
Bridger Management, LLC
Rtw Investments, Lp
Great Point Partners LLC
Asymmetry Capital Management, l.p.
Deerfield Management Company, l.p. (Series C)
Greenleaf Trust
Eventide Asset Management, LLC
Pfm Health Sciences, Lp
Orbimed Advisors LLC
Tamarack Advisers, Lp
Ecor1 Capital, LLC
Meditor Group Ltd
Sivik Global Healthcare LLC
Lilly Endowment Inc
Consonance Capital Management Lp
Alethea Capital Management, LLC
Sector Gamma As
Summer Road LLC
General Atlantic LLC
Foresite Capital Management Iii, LLC
Baker Bros. Advisors Lp
Regents of the University of California
Cormorant Asset Management, Lp
Palo Alto Investors Lp
Stonepine Capital Management, LLC
Rhenman & Partners Asset Management Ab
Biondo Investment Advisors, LLC