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Aviva Holdings Ltd.
Pura Vida Investments, LLC
Ghost Tree Capital, LLC
First Light Asset Management, LLC
Avoro Capital Advisors LLC
Polaris Venture Management Co. v, l.l.c.
Flagship Pioneering Inc.
Crestline Management, Lp
Vivo Capital, LLC
Ra Capital Management, l.p.
Lilly Endowment Inc
Sc Us (Ttgp), Ltd.
Boxer Capital, LLC
Dafna Capital Management LLC
Orbimed Advisors LLC
Redmile Group, LLC
Opaleye Management Inc.
Baker Bros. Advisors Lp
Pfm Health Sciences, Lp
Bridger Management, LLC
Casdin Capital, LLC
Rtw Investments, Lp
Deerfield Management Company, l.p. (Series C)
Acuta Capital Partners, LLC
Versant Venture Management, LLC
Eversept Partners, Lp
Harvard Management Co Inc
Regents of the University of California
Eventide Asset Management, LLC
Sivik Global Healthcare LLC
Cormorant Asset Management, Lp
New Leaf Venture Partners, l.l.c.
Bvf Inc/il
Foresite Capital Management Ii, LLC
Bain Capital Life Sciences Investors, LLC
Foresite Capital Management Iv, LLC
Bellevue Group Ag
Perceptive Advisors LLC
Alethea Capital Management, LLC
Rock Springs Capital Management Lp
Sabby Management, LLC
Biondo Investment Advisors, LLC
Sector Gamma As
Greenleaf Trust
Oracle Investment Management Inc
Highvista Strategies LLC
Sarissa Capital Management Lp
Rho Capital Partners Inc
Rhenman & Partners Asset Management Ab
Ecor1 Capital, LLC
Trv Gp, LLC
Kingdon Capital Management, l.l.c.
Farallon Capital Management LLC
Palo Alto Investors Lp
Omega Fund Management, LLC
Healthcor Management, l.p.
Agf Investments LLC
Summer Road LLC
Sectoral Asset Management Inc
Tamarack Advisers, Lp
Sio Capital Management, LLC
Bridgeworth, LLC
Tekla Capital Management LLC
International Biotechnology Trust Plc
Nea Management Company, LLC
Sphera Funds Management Ltd.
Prosight Management, Lp
Mivtachim the Workers Social Insurance Fund Ltd. (Under Special Management)
Krensavage Asset Management, LLC
Stonepine Capital Management, LLC
Calton & Associates, Inc.
Knott David M
Caxton Corp
Foresite Capital Management Iii, LLC
Mcadam, LLC
Heritage Wealth Advisors
Bruce & Co., Inc.
Robert Wood Johnson Foundation
General Atlantic LLC
Neumann Capital Management, LLC
Mpm Asset Management LLC
Mv Capital Management, Inc.
Sv Health Investors, LLC
Artal Group s.a.
Birchview Capital, Lp
Wellesley Asset Management
Armistice Capital, LLC
Consonance Capital Management Lp
Conrad N. Hilton Foundation
Summit Rock Advisors, Lp
Finepoint Capital Lp
Jgp Global Gestao De Recursos Ltda.
Chubb Ltd
Copernicus Capital Management, LLC
Kite Lake Capital Management (Uk) LLP
Atlas Venture Associates Ix, LLC
Great Point Partners LLC
Endurant Capital Management Lp
Asymmetry Capital Management, l.p.
Lion Point Capital, Lp