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  • Aviva Holdings Ltd.
  • Ghost Tree Capital, LLC
  • First Light Asset Management, LLC
  • Battery Partners Ix, LLC
  • Maso Capital Partners Ltd
  • Avoro Capital Advisors LLC
  • Ra Capital Management, l.p.
  • Lilly Endowment Inc
  • Boxer Capital, LLC
  • Vivo Capital, LLC
  • Opaleye Management Inc.
  • Pfm Health Sciences, Lp
  • Broadwood Capital Inc
  • Regents of the University of California
  • Bridger Management, LLC
  • Dafna Capital Management LLC
  • Foresite Capital Management Ii, LLC
  • Deerfield Management Company, l.p. (Series C)
  • Casdin Capital, LLC
  • Js Capital Management LLC
  • Orbimed Advisors LLC
  • Alethea Capital Management, LLC
  • Baker Bros. Advisors Lp
  • Acuta Capital Partners, LLC
  • Bvf Inc/il
  • Asymmetry Capital Management, l.p.
  • Cormorant Asset Management, Lp
  • Redmile Group, LLC
  • Eventide Asset Management, LLC
  • Nantahala Capital Management, LLC
  • Sabby Management, LLC
  • New Leaf Venture Partners, l.l.c.
  • Harvard Management Co Inc
  • Perceptive Advisors LLC
  • Rtw Investments, Lp
  • Great Point Partners LLC
  • Sb Investment Advisers (Uk) Ltd
  • Flagship Pioneering Inc.
  • Greenleaf Trust
  • Sector Gamma As
  • Highvista Strategies LLC
  • Rhenman & Partners Asset Management Ab
  • Bellevue Group Ag
  • Oracle Investment Management Inc
  • Ecor1 Capital, LLC
  • Rock Springs Capital Management Lp
  • Sio Capital Management, LLC
  • Polaris Venture Management Co. v, l.l.c.
  • Farallon Capital Management LLC
  • Kingdon Capital Management, l.l.c.
  • Tamarack Advisers, Lp
  • Agf Investments LLC
  • Versant Venture Management, LLC
  • Healthcor Management, l.p.
  • Biondo Investment Advisors, LLC
  • Sarissa Capital Management Lp
  • Palo Alto Investors Lp
  • Krensavage Asset Management, LLC
  • Fc Advisory LLC
  • Foresite Capital Management Iii, LLC
  • International Biotechnology Trust Plc
  • Sectoral Asset Management Inc
  • Mivtachim the Workers Social Insurance Fund Ltd. (Under Special Management)
  • Tekla Capital Management LLC
  • Sphera Funds Management Ltd.
  • Omega Fund Management, LLC
  • Sv Health Investors, LLC
  • Consonance Capital Management Lp
  • Robert Wood Johnson Foundation
  • Mv Capital Management, Inc.
  • Bruce & Co., Inc.
  • Knott David M
  • Caxton Corp
  • Rho Capital Partners Inc
  • Neumann Capital Management, LLC
  • Camarda Financial Advisors, LLC
  • Stonepine Capital Management, LLC
  • Francisco Partners Management, Lp
  • Chicago Capital Management, LLC
  • Interwest Venture Management Co
  • Pura Vida Investments, LLC
  • Hellman Jordan Management Co Inc /ma/
  • Newfound Research LLC
  • Yale University
  • General Atlantic LLC
  • Armistice Capital, LLC
  • Board of Trustees of the Leland Stanford Junior University
  • Chubb Ltd
  • Endurant Capital Management Lp
  • Sivik Global Healthcare LLC
  • Telemetry Investments, l.l.c.
  • Abingworth LLP
  • Summer Road LLC
  • Frazier Management LLC
  • Nea Management Company, LLC
  • Meditor Group Ltd
  • Artal Group s.a.
  • Birchview Capital, Lp
  • Mpm Asset Management LLC
  • Tang Capital Management LLC