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Trv Gp, LLC
Sabby Management, LLC
General Atlantic LLC
Knoll Capital Management, Lp
Sc Us (Ttgp), Ltd.
Lion Point Capital, Lp
Tamarack Advisers, Lp
Calton & Associates, Inc.
Greenleaf Trust
Crestline Management, Lp
Knott David M
Kingdon Capital Management, l.l.c.
Mcadam, LLC
Kite Lake Capital Management (Uk) LLP
Heritage Wealth Advisors
Virtus ETF Advisers LLC
Agf Investments LLC
Essex Woodlands Management, Inc.
Mivtachim the Workers Social Insurance Fund Ltd. (Under Special Management)
Aviva Holdings Ltd.
Prosight Management, Lp
Bruce & Co., Inc.
Bridgeworth, LLC
Rho Capital Partners Inc
Mv Capital Management, Inc.
Caxton Corp
Summit Rock Advisors, Lp
Harbourvest Partners LLC
Chubb Ltd
Meditor Group Ltd
Nea Management Company, LLC
Interwest Venture Management Co
Atlas Venture Associates Ix, LLC
Polaris Venture Management Co. v, l.l.c.
Healthcare Value Capital, LLC
Eventide Asset Management, LLC
Sv Health Investors, LLC
Biondo Investment Advisors, LLC
Highvista Strategies LLC
Armistice Capital, LLC
Abingworth LLP
Sarissa Capital Management Lp
Stonepine Capital Management, LLC
Ulys, l.l.c.
Oracle Investment Management Inc
Bridger Management, LLC
Pura Vida Investments, LLC
Sio Capital Management, LLC
Neumann Capital Management, LLC
Robert Wood Johnson Foundation