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Pura Vida Investments, LLC
Aviva Holdings Ltd.
First Light Asset Management, LLC
Copernicus Capital Management, LLC
Pfm Health Sciences, Lp
Lilly Endowment Inc
Sivik Global Healthcare LLC
Kite Lake Capital Management (Uk) LLP
Crestline Management, Lp
Highvista Strategies LLC
Asymmetry Capital Management, l.p.
Redmile Group, LLC
Ra Capital Management, l.p.
Avoro Capital Advisors LLC
Orbimed Advisors LLC
Harvard Management Co Inc
Vivo Capital, LLC
Bridger Management, LLC
Deerfield Management Company, l.p. (Series C)
Dafna Capital Management LLC
Polaris Venture Management Co. v, l.l.c.
Sc Us (Ttgp), Ltd.
Baker Bros. Advisors Lp
Sector Gamma As
Opaleye Management Inc.
Boxer Capital, LLC
Eversept Partners, Lp
Biondo Investment Advisors, LLC
Flagship Pioneering Inc.
Greenleaf Trust
Rtw Investments, Lp
Casdin Capital, LLC
Bellevue Group Ag
Eventide Asset Management, LLC
Great Point Partners LLC
Acuta Capital Partners, LLC
Bvf Inc/il
Rock Springs Capital Management Lp
Farallon Capital Management LLC
Healthcor Management, l.p.
Kingdon Capital Management, l.l.c.
Cormorant Asset Management, Lp
Agf Investments LLC
Perceptive Advisors LLC
Sio Capital Management, LLC
Versant Venture Management, LLC
Sarissa Capital Management Lp
New Leaf Venture Partners, l.l.c.
Bridgeworth, LLC
Foresite Capital Management Iv, LLC