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Pura Vida Investments, LLC
First Light Asset Management, LLC
Aviva Holdings Ltd.
Pfm Health Sciences, Lp
Sivik Global Healthcare LLC
Lilly Endowment Inc
Highvista Strategies LLC
Avoro Capital Advisors LLC
Newfound Research LLC
Js Capital Management LLC
Ra Capital Management, l.p.
Battery Partners Ix, LLC
Bridger Management, LLC
Asymmetry Capital Management, l.p.
Deerfield Management Company, l.p. (Series C)
Hellman Jordan Management Co Inc /ma/
Boxer Capital, LLC
Greenleaf Trust
Sector Gamma As
Redmile Group, LLC
Harvard Management Co Inc
Orbimed Advisors LLC
Opaleye Management Inc.
Broadwood Capital Inc
Dafna Capital Management LLC
Yale University
Vivo Capital, LLC
Baker Bros. Advisors Lp
Bvf Inc/il
Foresite Capital Management Ii, LLC
Sio Capital Management, LLC
Casdin Capital, LLC
Great Point Partners LLC
Eventide Asset Management, LLC
Acuta Capital Partners, LLC
Cormorant Asset Management, Lp
Chubb Ltd
Farallon Capital Management LLC
Nantahala Capital Management, LLC
Alethea Capital Management, LLC
Agf Investments LLC
Rhenman & Partners Asset Management Ab
Kingdon Capital Management, l.l.c.
Bellevue Group Ag
Perceptive Advisors LLC
Rtw Investments, Lp
Healthcor Management, l.p.
Rock Springs Capital Management Lp
Regents of the University of California
Fc Advisory LLC