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Baker Bros. Advisors Lp
Lilly Endowment Inc
Sc Us (Ttgp), Ltd.
Farallon Capital Management LLC
Orbimed Advisors LLC
Bellevue Group Ag
Perceptive Advisors LLC
Redmile Group, LLC
General Atlantic LLC
Greenleaf Trust
Ra Capital Management, l.p.
Eventide Asset Management, LLC
Rtw Investments, Lp
Avoro Capital Advisors LLC
Flagship Pioneering Inc.
Deerfield Management Company, l.p. (Series C)
Rock Springs Capital Management Lp
Artal Group s.a.
Cormorant Asset Management, Lp
Nea Management Company, LLC
Francisco Partners Management, Lp
Casdin Capital, LLC
Boxer Capital, LLC
Armistice Capital, LLC
Pfm Health Sciences, Lp
Tekla Capital Management LLC
Pura Vida Investments, LLC
Healthcor Management, l.p.
Bvf Inc/il
Mivtachim the Workers Social Insurance Fund Ltd. (Under Special Management)
Crestline Management, Lp
Novo Holdings A/s
Robert Wood Johnson Foundation
Vivo Capital, LLC
Palo Alto Investors Lp
Ecor1 Capital, LLC
Harvard Management Co Inc
Heritage Wealth Advisors
Bain Capital Life Sciences Investors, LLC
Western Asset Management Company, LLC
Sectoral Asset Management Inc
First Light Asset Management, LLC
Bridger Management, LLC
Frazier Management LLC
Rhenman & Partners Asset Management Ab
Trv Gp Iii, LLC
Sphera Funds Management Ltd.
Aviva Holdings Ltd.
Consonance Capital Management Lp
Sarissa Capital Management Lp