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Baker Bros. Advisors Lp
Lilly Endowment Inc
Farallon Capital Management LLC
Sb Investment Advisers (Uk) Ltd
Orbimed Advisors LLC
Bellevue Group Ag
Avoro Capital Advisors LLC
General Atlantic LLC
Greenleaf Trust
Perceptive Advisors LLC
Ra Capital Management, l.p.
Redmile Group, LLC
Eventide Asset Management, LLC
Francisco Partners Management, Lp
Rtw Investments, Lp
Artal Group s.a.
Deerfield Management Company, l.p. (Series C)
Rock Springs Capital Management Lp
Flagship Pioneering Inc.
Nantahala Capital Management, LLC
Boxer Capital, LLC
Armistice Capital, LLC
Tekla Capital Management LLC
Cormorant Asset Management, Lp
Healthcor Management, l.p.
Nea Management Company, LLC
Mivtachim the Workers Social Insurance Fund Ltd. (Under Special Management)
Casdin Capital, LLC
Pfm Health Sciences, Lp
Robert Wood Johnson Foundation
Novo Holdings A/s
Pura Vida Investments, LLC
Js Capital Management LLC
Bvf Inc/il
Palo Alto Investors Lp
Harvard Management Co Inc
Vivo Capital, LLC
Ecor1 Capital, LLC
Broadwood Capital Inc
Bridger Management, LLC
Sectoral Asset Management Inc
Rhenman & Partners Asset Management Ab
Frazier Management LLC
Great Point Partners LLC
Sphera Funds Management Ltd.
First Light Asset Management, LLC
Agf Investments LLC
Kingdon Capital Management, l.l.c.
Sarissa Capital Management Lp
Consonance Capital Management Lp