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  • Baker Bros. Advisors Lp
  • Lilly Endowment Inc
  • Farallon Capital Management LLC
  • Sb Investment Advisers (Uk) Ltd
  • Orbimed Advisors LLC
  • Bellevue Group Ag
  • Avoro Capital Advisors LLC
  • General Atlantic LLC
  • Greenleaf Trust
  • Perceptive Advisors LLC
  • Ra Capital Management, l.p.
  • Redmile Group, LLC
  • Eventide Asset Management, LLC
  • Francisco Partners Management, Lp
  • Rtw Investments, Lp
  • Artal Group s.a.
  • Deerfield Management Company, l.p. (Series C)
  • Rock Springs Capital Management Lp
  • Flagship Pioneering Inc.
  • Nantahala Capital Management, LLC
  • Boxer Capital, LLC
  • Armistice Capital, LLC
  • Tekla Capital Management LLC
  • Cormorant Asset Management, Lp
  • Healthcor Management, l.p.
  • Nea Management Company, LLC
  • Mivtachim the Workers Social Insurance Fund Ltd. (Under Special Management)
  • Casdin Capital, LLC
  • Pfm Health Sciences, Lp
  • Robert Wood Johnson Foundation
  • Novo Holdings A/s
  • Pura Vida Investments, LLC
  • Js Capital Management LLC
  • Bvf Inc/il
  • Palo Alto Investors Lp
  • Harvard Management Co Inc
  • Vivo Capital, LLC
  • Ecor1 Capital, LLC
  • Broadwood Capital Inc
  • Bridger Management, LLC
  • Sectoral Asset Management Inc
  • Rhenman & Partners Asset Management Ab
  • Frazier Management LLC
  • Great Point Partners LLC
  • Sphera Funds Management Ltd.
  • First Light Asset Management, LLC
  • Agf Investments LLC
  • Kingdon Capital Management, l.l.c.
  • Sarissa Capital Management Lp
  • Consonance Capital Management Lp